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Major Milestones



S.No Activity Period Responsibility
1. Recognition of need of creation of Traditional Knowledge (TK) data bases and need of support to developing countries by Standing Committee on Information Technology (SCIT) of World Intellectual Property Organization (WIPO). June, 1999 Third Plenary Session of SCIT, WIPO under the Chairmanship of Dr. R. A. Mashelkar, the then Director General of CSIR, India
2. Direction to Department of Indian Systems of Medicine & Homoeopathy (ISM&H)* for initiating measures to protect Indian Traditional Knowledge, in particular, Ayurveda - Planning Commission constitutes Task Force under the Chairmanship of Prof. D.N.Tiwari,the then Member Planning Commission on S&T.
3. Approach paper on setting up of TKDL. October, 1999 Paper prepared by Mr. V. K. Gupta, the then Senior Technical Director, National Informatics Centre at the direction of the then Secretary, Department of ISM&H*
4. Submission of approach paper to SCIT, WIPO December, 1999 Dr. R. A. Mashelkar, the then Director General of CSIR, India
5. Setting up of the interdisciplinary (inter-ministerial Task Force on TKDL, consisting of experts from Department Of ISM&H, Central Council of Research in Ayurveda & Siddha (CCRAS), Banaras Hindu University (BHU), National Informatics Centre (NIC), Controller General of Patents Designs & Trade Marks (CGPDTM), etc. under the Chairmanship of the then Senior Technical Director in NIC, Mr. V. K. Gupta January, 2000 Department of ISM&H*
6. Submission of TKDL Task Force Report to Department of ISM&H* May, 2000 TKDL Task Force
7. Presenting TKDL Concept & Vision at International forum May, 2000 Dr.R.A.Mashelkar, the then Director General of CSIR, India
8. Cabinet Committee of Economic Affairs (CCEA's) approval on TKDL Project January, 2001 Department of ISM&H
9. Memorandum of Understanding (MoU) between Department of ISM&H* and National Institute of Science Communication (NISCOM)** June, 2001 Department of ISM&H* and NISCOM**
10. TKDL software, specifications and design July, 2001 Mr. V. K. Gupta, the then Director, NISCOM**
11. Establishing TKDL team of Project Assistants (IT), Ayurveda, Patent Examiners, etc. October, 2001 to March, 2002 NISCOM**, CCRAS, Department of ISM&H* and CGPDTM.
12. Presentation on Traditional Knowledge Resource Classification (TKRC) at International Patent Classification (IPC) Union for getting established WIPO-TK Task Force consisting of USPTO, EPO, JPO, China and India February, 2001 Mr. V. K. Gupta, the then Director, NISCOM**
13. WIPO-TK Task Force recommended for adding a subclass under A 61 February, 2002 Meeting on behalf of India was attended by Mr. V. K. Gupta, the then Director, NISCOM as the member of International Task Force and the presentation was made on the issue of linkage between TKRC and IPC
14. Committee of Experts recommended:(i) inclusion of approx. 200 subgroups on TK against earlier few sub-groups on medicinal plants, (ii) linking of TKRC to IPC and (iii) continuation of work on biodiversity, TK and TCE February, 2003 -------do-------
15. Internationally recognized specifications and standards for setting up of TK data bases and registries based on TKDL specifications

(a) Drafting of specifications at WIPO Regional Symposium at Kochi, based on TKDL



(b) Presentation of WIPO document No. WIPO/GRTKF/IC/4/14 at the 4th Session of Intergovernmental Committee (IGC) of WIPO on Intellectual Property and Genetic Resources, Traditional Knowledge and Expression of Folklore

(c) Adoption of recommendations contained in document No. WIPO/ GRTKF/IC/4/14 by International IP community at the 5th Session of IGC


November, 2002

December, 2002

July, 2003


Regional TK experts from China, Philippines, India (Prof. Anil Gupta, Prof. Madhav Gadgil, Dr. Darshan Shankar, Mr. V. K. Gupta, etc.)

Mr. V. K. Gupta, the then Director, National Institute of Science Communication And Information Resources (NISCAIR)

Intergovernmental Committee (IGC) of WIPO
16. Constitution of Access Policy Issue Committee (APIC) August, 2002 (i) Frame policies on accessing TKDL database
(ii) Decide on matters relating to dissemination of TKDL
(iii) Meet defensive and positive objectives of TKDL
17. Completing data abstraction work on 36,000 Ayurveda formulations for creating TKDL in five languages, i.e. English, German, Spanish, French and Japanese March, 2003 TKDL team of Project Assistants (IT), Ayurveda, Patent Examiners and Scientists functioning since October 2001 at NISCAIR (erstwhile National Institute of Science Communication, NISCOM).
18. Release of demo CD containing a sample of 500 formulations October, 2003 Released by the then Hon’ble Union Minister of Human Resource Development, Science & Technology, and Ocean Development and presided by the then Hon’ble Union Minster of Health & Family Welfare and Parliamentary Affairs.
19. Initiation of the TKDL Unani project June 2004 Department of AYUSH and NISCAIR
20. Initiation of TKDL Ayurveda Phase II August 2004 Department of AYUSH and NISCAIR
21. Meeting with Hon’ble Minister of Health and Family Welfare on providing access to TKDL database to European Patent Office (EPO) August 2004 Department of AYUSH and NISCAIR
22. Concordance between IPC and TKRC and approval on linking of TKRC with IPC October, 2004 35th IPC Union Meeting Describe Concepts presented by Mr. V.K. Gupta, Director NISCAIR
23. Workshop on Creation of TKDL for SAARC Countries December, 2004 SAARC Documentation Centre, NISCAIR and Ministry of Human Resource Development
24. Request for access to TKDL by EPO July 2005 CSIR
25. Initiation of project on TKDL Siddha August, 2005 Department of AYUSH and NISCAIR
26. Creating of TKRC containing approx. 25,000 subgroups December, 2005 NISCAIR
27. Inclusion of 207 subgroups,related to algae,fungi,lichens or plants or derivatives thereof used in Traditional Herbal Medicines in International Patent Classification, 8th Edition January, 2006 IPC union,WIPO
28. Approval on Access to TKDL database to International Patent Offices(IPOs) by Cabinet Committee on Economic Affairs June 2006 -
29. Vetting of Access Agreement August,2005; March,2008; June,2005; December,2005; February,2008; January, 2006 (i) Legal and Treaties Division, Ministry of External Affairs
(ii) Department of Legal Affairs, Ministry of Law and Justice
(iii) Shri Praveen Anand, Leading Patent Attorney
(iv) Shri Soli J. Sorabjee, Former Attorney General
30. Access Agreement sent to EPO July, 2006; December, 2006 CSIR
31. Request by United States Patent and Trademark Office(USPTO) for access to TKDL database and sending of Access Agreement December,2006 CSIR
32. APIC meeting to discuss the responses given by EPO and USPTO June, 2007 APIC
33. Initiation of activities on creation of TKDL Yoga January 2008 CSIR, Department of AYUSH and Morarji Desai national Institute of Yoga (MDNIY)
34. APIC meeting to discuss the clarifications sought by EPO, gives clearance for signing of Access Agreement July, 2008 APIC
35. TKDL Access Agreement concluded with European Patent Office (EPO)
Press Release
February,2009 CSIR
36. Request for access to TKDL by German Patent and Trademark Office (DPMA) March 2009 CSIR
37. Request from Malaysia for having a joint workshop on experience sharing in the area of traditional medical knowledge March,2009 CSIR
38. Request from Thailand for having a joint workshop on experience sharing in the area of traditional medical knowledge April,2009 CSIR
39. USPTO in principle agreement to TKDL Access Agreement conveyed to Indian Mission in US May 2009 Acting Director USPTO
40. Formal agreement to TKDL Access Agreement by USPTO July 2009 USPTO
41. Prior art evidence based on TKDL citations under Third Party observations against 35 Pipe line patent applications at EPO June-July 2009 V.K.Gupta, Senior Advisor and Director, TKDL
42.**** Based on TKDL's third party observation filed for the application no. EP1520585 relating to cancer treatment using Pistacia species, EPO asked applicant to take position on TKDL cited references July 2009 EPO
43. EPO set aside intention to grant patent on anti-vitiligo cream to Perdix Euro group SL Spain for their application no EP1747786 , based on TKDL third party submission and re-opened the case for substantive examination. July 2009 EPO
44. Access to TKDL database granted to CGPDTM (Indian Patent Office) under Access Agreement July, 2009 CSIR
45. TKDL Access Agreement concluded with German Patent and Trademark Office (DPMA) October, 2009 CSIR
46. TKDL Access Agreement concluded United States Patent Office (USPTO) in the Hall of Flags, US Chambers of Commerce, Washington DC. on the sidelines of the State visit of Hon’ble Prime Minister to US
Press Release
i)USPTO (Photo)
ii)Embassy of India
November, 2009 CSIR
47. Uniliver Nv,Netherland have withdrawn their application no  EP1607006 for "Functional berry composition" dated 04 August 2009 after submission of TKDL prior art evidence(s). 04-Aug-2009 CSIR
48. Purimed Co. Ltd. Seoul, Korea have withdrawn their application no  EP1781309 for "Nelumbinis semen extract for preventing and treating ischemic heart disease and pharmaceutical composition and health food containing the same" dated 30 October 2009 after submission of TKDL prior art evidences. 18-Sept-2009 CSIR
49. Clara's ApS, Denmark have withdrawn their application no  EP2044850 for "Method for altering the metabolism characteristic of food products 30-Oct-2009 CSIR
50. Jumpsun Bio-Medicine (Shanghai) Co. Ltd, China have withdrawn their application no  EP1889638 for "Medicaments and food for treatment or prevention of obesity and/or diabetes containing cicer arietinum extract" 20-Nov-2009 CSIR
51.## Industrial Research Limited and Otago Innovation Limited / New Zealand have withdrawn their application no. EP1750809 for "Citrus Fruit Skin extract for Angiogenesis promotion" based on the TKDL evidences. 20-Nov-2009 CSIR
52. Amcod Limited, Mombasa, Kenya have withdrawn their application no  EP1807098 for "Herbal compositions for treatment of diabetes" 24-Nov-2009 CSIR
53. Cognis IP Management GmbH, Germany have withdrawn their application no  EP1967197 for "Use of preparations, purifications and extracts of aloe" 27-Nov-2009 CSIR
54. Evonik Goldschmidt GmbH,Germany have withdrawn their application no  EP2065031 for "Skin treatment composition" 27-Jan-2010 CSIR
55. TKDL Access Agreement concluded with United Kingdom Intellectual Property Office(IPO) February, 2010 CSIR
56. Natreon Inc. 2-D Janine Place New Brunswick, NJ 08901/United States have withdrawn their application no  EP1906980 for "Method of treatment or managment of stress" 25-March-2010 CSIR
57. Avesthagen Limited Unit 3, Discoverer, 9th Floor International Tech Park Whitefield Road Bangalore 560 066/India have withdrawn their application no  EP1660106 for "Biotherapeutics for Mitigation of health Disorders from Terminalia Arjuna" 06-Apr-2010 CSIR
58. Jan Marini Skin Research Inc. 6951 Via del Oro San Jose, California 95119/United States have withdrawn their application no  EP1825845 for "Cosmetic herbal compositions" 08-Apr-2010 CSIR
59. Naveh Pharma (1996) Ltd. P.O. Box 8139 42505 Netanya / Israel2009/04 have withdrawn their application no  EP2015761 for "Methods and composition for treating sore throat" 15-Apr-2010 CSIR
60. GW Pharma Limited Porton Down Science Park Salisbury, Wiltshire SP4 OJR/Great Britain have withdrawn their application no  EP1937231 for "Pharmaceutical compositions for the treatment of Chronic Obstructive Pulmonary Disease" 24-June-2010 CSIR
61.*** Based on TKDL's third party observation filed for the application no. EP1849473 "relating Chinese traditional medicine composition for treatment of avian influenza/Bird Flu, method for preparation, and application thereof " EPO asked applicant to take position on TKDL cited references. 05-July-2010 CSIR
62. Integrated Botanical Technologies, 23 Snowden Avenue, Ossining, New York 10562-3218 / US has amended the claims of the application no EP1722805 entitled "Bioactive compositions from Theacea plants and processes for their production and use" based on the TKDL evidences. 23-July-2010 CSIR
63. Indena S.p.A. Viale Ortles, 12 20132 Milano / Italy[2009/51] have withdrawn their application no  EP2133089 for "Compositions for the treatment of disorders of the upper respiratory tract and influenza syndromes" 26-July-2010 CSIR
64. Haelan Schweiz GmbH Schützenstrasse 188808 Pfäffikon Switzerland [2009/51] have withdrawn their application no  EP2133080 for "Compounds containing equol" 26-July-2010 CSIR
65. Bios Line S.p.a.Viale Finladia 435020 Ponte S. Nicolo (PD) / Italy [2009/25] have withdrawn their application no  EP2070545 for "Oral compositions for the prevention and treatment of inflammatory disorders of the colon" 29-July-2010 CSIR
66. Aché Laboratórios Farmacêuticos S.A. Rodovia Presidente Dutra Km 222,2 Porto da Igreja 07034-904 Guarulhos- SP /Brazil [2009/39] have withdrawn their application no  EP2101800 for "Extracts from the skin of fruits of plants from genus vitis, compositions containing the same and a process for its manufacture" 30-July-2010 CSIR
67. Mercian corporation 5-8, Kyobashi 1-chome Chuo-ku, Tokyo 104-8305 / Japan[2008/31] have withdrawn their application no  EP1949889 for "Fibroblast activator, method for activation of fibroblast, collagen synthesis promoter, method for promotion of collagen synthesis, skin aging-preventing agent, and method for prevention of aging of the skin " 4-August-2010 CSIR
68. Al-Jassim, Rawaa 2578 River Wood Drive Napperville, Illinois 60565 / United States, Great Britain, Germany, Netherlands and Qatar have withdrawn their application no  EP1709995 for "Asthma/allergy therapy using nigella sativa " 18-August-2010 CSIR
69. TKDL Access Agreement concluded with Canadian Intellectual Property Office (CIPO) September, 2010 CSIR
70. Bionature E.A. Limited 1 Poseidon 2406 Egomi, Nicosia/ Cyprus [2008/34] have withdrawn their application no  EP1958641 for "Treatment and prevention of inflammation" 22-September-2010 CSIR
71. Natbio Pty Ltd. 41/8 Goodwin Street Kangaroo Point, QLD 4169 / Australia [2006/50] have withdrawn their application no  EP1729593 for "Cysteine Protease From Ginger (Zingiber) As A Food Improver And Anti-Inflammatory" 11-Oct-2010 CSIR
72. Seoul National University Industry Foundation San 4-2, Bongcheon-dong, Gwanak-gu Seoul 151-818 / South Korea [2008/39] have withdrawn their application no  EP1971354 for "Composition comprising liquiritigenin for preventing and treating liver disease" 21-Oct-2010 CSIR
73. Morning-After Herbal Infusion Corporation 180 Boul. rené-Lévesque East Suite 208 Monréal, QC H2X 1N6 / Canada [2009/34] have withdrawn their application no  EP2089505 for "Reduced-hangover alcoholic beverage" 29-Oct-2010 CSIR
74. Juice Beauty 711 Grand Avenue, Suite 290 San Rafael, CA 94901 / US have withdrawn their application no  EP1942917 for "Compositions and methods for using juice organic, juice based skin care products" 04-Nov-2010 CSIR
75. GW Pharma Limited Porton Down Science Park Salisbury Wiltshire SP4 0JR / Great Britain [2010/16] have withdrawn their application no  EP2175848 for "Therapeutic uses of Cannabigerol " 11-Nov-2010 CSIR
76. Cognis IP Management GmbH Henkelstrasse 67 40589 Düsseldorf / Germany[2010/33] have withdrawn their application no  EP2218455 for " Dolichos biflorus extract for use in therapeutic skin treatment" 18-Nov-2010 CSIR
77. Velleja Research SRL Via Natta, 28 29010 Pontenure (PC) / Italy [2009/03] have withdrawn their application no  EP2014295 for "Topical compositions for the prevention and treatment of inflammatory and/or infective conditions of the genital area " 23-Nov-2010 CSIR
78. TKDL Access Agreement concluded with Intellectual Property Australia (IP Australia) January, 2011 CSIR
79. Spannagel, Lucia Antonia Guemes 235, barrio Los Eucaliptos Villa Carlos Paz Provincia de Cordoba/ Argentina have withdrawn their application no  EP2008661 for "Formulation based on marigold aloe and centellae " 05-Jan-2011 CSIR
80. Based on the TKDL evidences filed for the application no  CA 2387703 entitled "Method for calming human beings using personal care compositions" by Johnson & Johnson Consumer Companies Inc, United States of America, CIPO has declared the application as ‘Dead’. 11-Feb-2011 CSIR
81. Priebe, Ingrid Thierschstrasse 10 83471 Schönau / Germany[2007/10] have withdrawn their application no  EP1759706 for "Use of mash of Gentiana root and corresponding agents" 15-Feb-2011 CSIR
82. Based on the TKDL evidences filed for the application no  CA 2448513 entitled "Isoflavone Concentrates, as well as methods for their production" by Aquanova German Solubilisate Technologies (AGT) GMBH, Germany, CIPO has declared the application as ‘Dead’. 28-Feb-2011 CSIR
83. Based on the TKDL evidences filed for the application no  CA 2579562 entitled "Method for improving sleep behaviors" by Johnson & Johnson Consumer Companies Inc, United States of America, CIPO has declared the application as ‘Dead’. 28-Feb-2011 CSIR
84. Based on the TKDL evidences filed for the application no  CA 2366318 entitled "Novel pharmaceutical, dietary and cosmetic compositions comprising zinger officinale roscoe, eicosapentaenoic acid and/or docosahexaenoic acid" by IDA ROYALTY APS, Denmark, CIPO has declared the application as ‘Dead’. 02-Mar-2011 CSIR
85. International Conference on 'Utilization of the Traditional Knowledge Digital Library (TKDL) as a Model for the Protection of Traditional Knowledge' 22-24 March, 2011 WIPO and CSIR
86. B.C. DEVELOPMENT S.A. route de France 17 / CP 18 2926 Boncourt / Switzerland,Sprim 2 Square Pétrarque 75016 Paris / France have withdrawn their application no  EP2167072 for"Use Of Oleocanthal For Treatment Of Cutaneous Inflammation" 09-March-2011 CSIR
87. TKDL Access Agreement concluded with Japan Patent Office(JPO)
Press Release
April, 2011 CSIR
88. CGPDTM refuses the application no. 172/DEL/2007 entitled "A preparation for treatment of Vitiligo and a method of preparation thereof" filed by Central Council for Research in Unani Medicines (CCRUM), India, based on the TKDL evidences. 07-Apr-2011 CSIR
89. CHIH-HSIUNG LIN, Taiwan, Province of China has amended the claims of the application no.  EP1880719 entitled "Composition for prophylaxis or treatment of urinary system infection and method thereof" based on the TKDL evidences. 27-Apr-2011 CSIR
90. Based on the TKDL evidences filed for the publication no  GB2436063 entitled " Pharmaceutical composition for the treatment of excess mucous production " by NICHOLAS JOHN LARKINS, Apartment 60,Westminster Gardens, Marsham Street,LONDON, SW1P 4JG, United Kingdom, the Examiner has Terminated the Patent application(s) before grant. 12-May-2011 CSIR
91. DONG-A PHARM. CO., LTD. 252, Yongdu-dong Dong-daemun-ku Seoul 130-823 / Republic Of Korea, have withdrawn their application no  EP2029150 for "Extract of Herbal and the composition containing the same" 09-June-2011 CSIR
92. Suntory Holdings Ltd. / Japan has amended the claims of the publication no. EP2153831 entitled "Anti-Fatigue agent and oral composition each comprising Andrographolide as active ingredient" based on the TKDL evidences. 10-June-2011 CSIR
93. Nestec S.A. Avenue Nestlé 55 1800 Vevey / Switzerland, have withdrawn their application no  EP2263481 for "Green tea extracts of improved bioavailability" 22-June-2011 CSIR
94. L'Oreal 14, rue Royale 75008 Paris / France and Nestec S.A. Avenue Nestlé 55 1800 Vevey / Switzerland, have withdrawn their application no  EP1553851 for "Cosmetic composition for preventing and/or correcting the functional disorders of the pilo-sebaceous unit of mammals" 22-June-2011 CSIR
95. Dynamiclear Pty Ltd, 19 Byrnes Street Mareeba QLD 4880 Australia has amended the claims of the application no  2009217410 entitled "Composition for treating skin lesions" based on the TKDL evidences. 28-Jun-11 CSIR
96. Based on the TKDL evidences filed for the application no.  CA 2572031 entitled "Fat combustion accelerator" by SUNTORY LIMITED, Japan, CIPO has declared the application as 'Dead'. 29-Jun-2011 CSIR
97.## Morinaga Milk Industry Co., Ltd, Tokyo, Japan withdrew 15 claims and retained the application with only one claim on the basis of Examiner’s report on their publication no.  20090093450 for "use of Liliaceae Plant for inhibiting visceral fat accumulation". 30-Jun-2011 CSIR
98. Tower Laboratories, Ltd. 8 Industrial Park Road Centerbrook, CT 06409 / United States, have withdrawn their application no  EP1755402 for "Compositions for inhalation therapy and methods of use" 30-June-2011 CSIR
99. Slimak, Karen M. P.O. Box 2444 Springfield, VA 22152 / United States, have withdrawn their application no  EP1140123 for "Use of tropical root crops in effective intervention strategies for treating difficult and complex cases and chronic diseases" 05-Jul-2011 CSIR
100. Fonterra Co-Operative Group Limited 9 Princes Street Auckland / New Zealand have withdrawn their application no.  EP2146739 for "Use of Cow's milk and Ghee for the treatment Cancer" 15-Jul-2011 CSIR
101. Kao Corporation 14-10, Nihonbashi-Kayabacho, 1-chome Chuo-ku Tokyo 103-8210 / Japan has amended the claims of the application no.  EP2062883 entitled "Insulin sensitivity improving agent" based on the TKDL evidences." 18-Jul-2011 CSIR
102. Based on the TKDL evidences filed for the application no  CA 2616602 entitled "Method of treatment or management of stress" by NATREON, INC., United States of America, CIPO has declared the application as ‘Dead’. 27-Jul-2011 CSIR
103. MORINAGA MILK INDUSTRY CO., LTD. 33-1, Shiba 5-chome Minato-ku, Tokyo-to 108-0014 / Japan has amended the claims of the application no.  EP1795200 entitled "Medicine and food/beverage for ameliorating hyperglycemia" based on the TKDL evidences. 29-Jul-2011 CSIR
104. Pokka Corporation, 4-2-29, Sakae Naka-ku Nagoya-shi, Aichi 460-8415 / JAPAN has amended the claims of the publication no. EP2223930 entitled "Eriocitrin-containing material, method for production of the Eriocitrin-containing material, and food, beverage, pharmaceutical preparation and cosmetic each comprising the Eriocitrin-containing material" based on the TKDL evidences. 11-Aug-2011 CSIR
105. BIOPROGRESS TECHNOLOGY LIMITED Units 15-17 Cambridge Science Park Milton Road Cambridge, CB4 0FQ / Great Britain have withdrawn their application no.  EP1925311for "Use of a plant extract or plant juice" 19-Aug-2011 CSIR
106. Based on the TKDL evidences filed for the application no  CA 2697020 entitled "Method of producing Plant extract formulations" by QUINN PHARMACEUTICALS, Australia, CIPO has declared the application as ‘Dead’. 22-Aug-2011 CSIR
107. Based on the TKDL evidences filed for the application no  CA 2409051 entitled "Antimigraine Combination Comprising Sapindus and Emblica Extracts" by LUPIN LIMITED, India, CIPO has declared the application as ‘Dead’. 22-Aug-2011 CSIR
108. Willfred-Ramix, Inc., United States of America have withdrawn their application no.  2009240851 for "A composition for treating AIDS and associated conditions." 06-Sep-2011 CSIR
109. Zacharia, Jacob Jawahar Housing Colony Cherinchal Karanthoor P.O. Kannamangalam Koznikkode District Kerala / India have withdrawn their application no. EP2152282 for "Method and preparation of herbal extract of calotropis gigantea for cancer treatment" 08-Sep-2011 CSIR
110. Kao Corporation 14-10, Nihonbashi-Kayabacho, 1-chome Chuo-ku Tokyo 103-8210 / Japan has amended the claims of the application no. EP2112929 entitled "Catechin as insulin sensitivity improving agent" based on the TKDL evidences 21-Sep-2011 CSIR
111. Avesthagen Limited 'Discoverer' 9th Floor International Tech Park Whitefield Road Bangalore Karnataka 560 066 / India have withdrawn their application no  EP2152284 for "A synergistic ayurvedic / functional food bioactive composition [cincata]" 23-Sep-2011 CSIR
112. Original Image Co., Ltd. 3-21-2 Motohama-cho Naka-ku Yokohama-shi Kanagawa 231-0004 / Japan have withdrawn their application no  EP1609476 for "Composition for treating Hepatitis C" 29-Sep-2011 CSIR
113. Iomedix Sleep International SRL The Grove 21 Pine Road Belleville 11113 Saint Michael / Barbados have withdrawn their application no  EP1991241 for "compositions and methods for the induction and maintenance of quality sleep" 30-Sep-2011 CSIR
114. Lifeline Nutraceuticals Corporation 6400 South Fiddler's Green Circle, Suite 1970 Englewood, CO 80111 / United States has amended the claims of the application no.  EP2266586 for "Brahmi and Mandukaparni as cardio-tonic, memory enhancer, immuno potentiators and for the treatment of oedema / inflammation, neurological diseases and psychosis; Tea as brain tonic, anti-inflammatory and for the treatment of diseases of heart and insomnia; Milk thistle as anti-inflammatory; Ashwagandha and Gheekawaar for the treatment of paralysis/hemiplegia, bell’s palsy, numbness,insomnia, neurological diseases and diabetes mellitus and Turmeric/ Haldi for the treatment of oedema / inflammation and ulcer / wound Healing" 05-Oct-2011 CSIR
115. Based on the TKDL evidences filed for the application no  CA 2625433 entitled "Carotenoid Oxidation products as Chemopreventive and Chemotherapeutic Agents" by Lycored LTD., Israel, CIPO has declared the application as ‘Dead’. 05-Oct-2011 CSIR
116. Georgiou, George J. Panayia Aimatousa 300 Aradippou 7101, Larncaca / Cyprus have withdrawn their application no  EP1855701 for "Metal Chelator" 10-Oct-2011 CSIR
117. For all designated states Avesthagen Limited Unit 3, Discoverer, 9th Floor International Tech Park Whitefield Road Bangalore 560 066 / India have withdrawn their application no  EP1906982 for "Plant extracts and methods and uses therefore" 17-Oct-2011 CSIR
118. PM-International AG 17, rue des Gaulois 1618 Luxembourg have withdrawn their application no  EP2223616 for " Food supplement preparation with an active ingredient mixture" 25-Oct-2011 CSIR
119. Based on the TKDL evidences filed for the application no  CA 2642184 entitled "Composition containing ginseng and cinnamon" by Goliath Oil and Gas Corporation, Canada, CIPO has declared the application as ‘Dead’. 28-Oct-2011 CSIR
120. Based on the TKDL evidences filed for the application no  CA 2470603 entitled "Methods for the treatment of peripheral Neural and Vascular Ailments" by The Quigley Corporation, USA, CIPO has declared the application as ‘Dead’. 07-Nov-2011 CSIR
121. Istituto Farmacoterapico Italiano S.P.A. Via Paolo Frisi 21/23 00197 Rome / Italy have withdrawn their application no.  EP1998758 for "Spray composition for topical use for treating and/or preventing herpes simplex labial infections." 09-Nov-2011 CSIR
122. "Delhi Institute Of Pharmaceutical Sciences And Research (DIPSAR) Pushp Vihar Sector III New Dehli 110 017 / India" and "Promed Exports Private Limited 210 Ashirwad Commercial Complex D-1 Green Park New Delhi 110 016 / India" has amended the claims of the application no. EP2182963 entitled "Herbal Composition on the basis of extracts of Foeniculum Vulgare, Murraya Koenigii and Triphala" based on the TKDL evidences. 15-Nov-2011 CSIR
123. LAILA NUTRACEUTICALS, Vijayawada, India has amended the claims of the publication no 20100203078 entitled "Anti-obese compositions containing holoptelea integrifolia extracts." based on the TKDL evidences. 18-Nov-2011 CSIR
124. Based on the TKDL evidences filed for the application no  CA 2467664 entitled "Methods of making and using Theaflavin, Theaflavin-3-Gallate, Theaflavin-3'-Gallate and Theaflavin 3,3'-Digallate and Mixtures Thereof" by Nashai Biotech, LLC, United States of America, CIPO has declared the application as ‘Dead’. 28-Nov-2011 CSIR
125. Nu Skin International, Inc. 75 West Center Street Provo, UT 84601 / United States have withdrawn their application no EP1718143 for "Agents for Sequestering Serum Aging factors and uses therefore" 06-Dec-2011 CSIR
126. Based on the TKDL evidences filed for the application no  CA 2530345 entitled "Composition and method for Mitigating a negative effect of Alcohol consumption" by EFFECTLIVE INC. (Canada), CIPO has declared the application as ‘Dead’. 15-Dec-2011 CSIR
127. Apptec Inc, C/o Bregen TechnicaL ConsultantS L.L.C., 154 old clinton road flemington New Jersey 08822 has amended the claims of the publication no. 20110097424 entitled "Herbal formulations for the management of chronic ulcers and wounds" based on the TKDL evidences. 19-Dec-2011 CSIR
128. Based on the TKDL evidences filed for the application no  CA 2473143 entitled "Compositions containing Oat Straw and Willowherb Extract" by JOHNSON & JOHNSON GMBH ((Germany)), CIPO has declared the application as ‘Dead’. 22-Dec-2011 CSIR
129. Pearl Cohen Zedek Latzer, LLP, 1500 Broadway, 12th Floor, New York 10036, United States, filed a patent application with publication no.  20100239696 entitled "Flaxseed lignan complex, methods of using and compositions thereof", the Examiner rejected 7 claims based on the TKDL evidences 06-Jan-2012 CSIR
130. ARKRAY, Inc. 57 Nishiaketa-cho Higashikujo Minami-ku Kyoto-shi, Kyoto 601-8045 / Japan have withdrawn their application no EP2033650 for "Inhibitor of Expression Of Nuclear Transcription Factor Ap-1,and Pharmaceutical product and product using the inhibitor" 18-Jan-2012 CSIR
131. Based on the TKDL evidences filed for the application no  CA 2485389 entitled "Formulations useful in the treatment of male and female impotence" by INDENA S.P.A.(Italy), CIPO has declared the application as ‘Dead’. 23-Jan-2012 CSIR
132. Based on the TKDL evidences filed for the application no  CA 2485264 entitled "Formulations useful in the treatment of male and female impotence" by INDENA S.P.A.(Italy), CIPO has declared the application as ‘Dead’. 23-Jan-2012 CSIR
133. Nestec S.A., Avenue Nestlé 55, 1800 Vevey/ Switzerland have withdrawn their application no EP2251032 for "Lactoferrin and brain health and protection in adults" 24-Jan-2012 CSIR
134. Nestec S.A Avenue Nestlé 55 1800 Vevey/ Switzerland have withdrawn their application no  EP2251029 for "Lactoferrin and gut neuronal health in adults and/or elderly" 24-Jan-2012 CSIR
135. Based on the TKDL evidences filed for the application no  CA 2601777 entitled "COMPOSITIONS AND METHODS FOR ENHANCING COGNITIVE FUNCTION" by SIGNUM BIOSCIENCES, INC., USA, CIPO has declared the application as ‘Dead’. 03-Feb-2012 CSIR
136. Based on the TKDL evidences filed for the application no  CA 2485530 entitled "THROAT SPRAY" by CNS, INC. USA, CIPO has declared the application as ‘Dead’. 14-Feb-2012 CSIR
137. Examiner has amended the claims for the publication no 20110052737 entitled "Topical skin formulations comprising Botanical Extracts" based on the TKDL evidences. 22-Mar-2012 CSIR
138. Yale University Two Whitney Avenue New Haven, CT 06511 / United States have withdrawn their application no EP1812028 for "Herbal composition phy906 and its use in Chemotherapy" based on the TKDL evidences. 23-Mar-2012 CSIR
139. Based on the TKDL evidences filed for the publication no  GB2450493 entitled " Cannabigerol for use in treatment of diseases benefiting from agonism of CB1 and CB2 cannabinoid receptors " by GW PHARMA LTD, Porton Down Science Park, SALISBURY, Wiltshire, SP4 0JR / United Kingdom, the Examiner has Terminated the Patent application(s) before grant. 24-Mar-2012 CSIR
140. Based on the TKDL evidences filed for the application no  CA 2445373 entitled "Use of Phyllanthus constituents for treating or preventing infections caused by Hepatitis B viruses" by PHYTRIX AG (Germany), CIPO has declared the application as ‘Dead’. 26-Apr-2012 CSIR
141. University of Saskatchewan, Box 5000, RPO University Suite 501-121 Research Drive, Saskatoon, Saskatchewan S7N 1K5 / Canada has amended the claims of the publication no. EP2229403 entitled "Recovery of hydrophobic peptides from oils" based on the TKDL evidences. 10-May-2012 CSIR
142. Provexis (IBD) Limited, Thames Court 1 Victoria Street Windsor, Berkshire SL4 1YB / United Kingdom have withdrawn their application no EP2371374 for "Soluble fiber from Musa spp. for treating gastroenteritis or diarrhea" based on the TKDL evidences. 16-May-2012 CSIR
143. Biotek Iotex Holding APS V., Vimmelskaftet 43 1161, Copenhagen K / Denmark has amended the claims of the publication no. EP2155222 entitled "Extract of Trigonella Foenum-Graecum" based on the TKDL evidences. 24-May-2012 CSIR
144. Original Image Co., Ltd., 21-2 Motohama-cho 3-chome Naka-ku Yokohama-shi, Kanagawa 231-0004/ JAPAN have withdrawn their application no EP1498132 for "Compositions for preventing or treating Pollenosis, Allergic Nephritis, Atopic Dermatitits, Asthma or Urticaria" based on the TKDL evidences. 29-May-2012 CSIR
145. Colgate-Palmolive Company, 300 Park Avenue, New York, NY 10022/ United States of America has amended the claims of the publication no. EP2192910 entitled "Oral compositions containing botanical extracts" based on the TKDL evidences. 1-June-2012 CSIR
146. Romani, Annalisa, Via Delle Lame 4, 51031 Agliana / ITALY have withdrawn their application no EP1945237 for "Use of Extracts of Myrtle and other Mediterranean plant species, as Antimycotic agent towards Yeast and Yeast-like Microorganisms" based on the TKDL evidences. 6-June-2012 CSIR
147. Unigen, Inc. 200-1, Songjeong-ri Byeongcheon-myeon, Cheonan-si Chungcheongnamdo 330-863 / South Korea have withdrawn their application no EP1863498 for "Composition Comprising Isoorientin for Suppressing Histamine" based on the TKDL evidences. 11-June-2012 CSIR
148. Based on the TKDL evidences filed for the publication no  GB2448535 entitled " New use for cannabinoid-containing plant extracts " by GW PHARMA LTD, Porton Down Science Park, SALISBURY, Wiltshire, SP4 0JR / United Kingdom, the Examiner has Terminated the Patent application(s) before grant. 19-June-2012 CSIR
149. Kramer & Amado, P.C. 1725 Duke Street, Suite 240, Alexandria, VA, 22314, USA has amended the claims of the publication no 20100203117 entitled "Anti-adipogenic compositions containing piper betle and dolichos biflorus" based on the TKDL evidences. 02-July-2012 CSIR
150. PROBELTE PHARMA, S.A., Ctra. Madrid Km.389 Poligono Industrial el Tiro E-30100, Espinardo Murcia Spain has amended the claims of the application no  2008278764 entitled " Fortification of nutritional products with olive extracts containing hydroxytyrosol and hydroxytyrosol fortified nutritional products" based on the TKDL evidences. 03-Jul-2012 CSIR
151. Nature Therapeutics Limited, 4 Mill Fields Bassingham Lincoln, Lincolnshire LN5 9NP / United Kingdom have withdrawn their application no EP2094091 for "Antimicrobial Composition" based on the TKDL evidences. 04-July-2012 CSIR
152. Riolan Technologies, Inc., 8575 Prestwick Drive, La Jolla, CA 92037 / United States have withdrawn their application no EP2086560 for "Methods of treating Epiphora" based on the TKDL evidences. 10-July-2012 CSIR
153.## Manish Saxena, New Delhi, India has amended the claims of the application no. 20100178367 entitled "Herbal formulation for wound healing" on the basis of the Examiner report on 10-Apr-12. 10-Jul-2012 CSIR
154. SUGHRUE MION, PLLC 2100 PENNSYLVANIA AVENUE, N.W.SUITE 800, WASHINGTON DC 20037, United States has amended the claims of the publication no 20100129296 entitled "Extract of Trigonella Foenum-Graecum" based on the TKDL evidences. 13-July-2012 CSIR
155.## Chie Suzuki, Kyo Nagashima, Masami Mochizuki, Japan has amended the claims of the application no. 20110177184 entitled "Bloat therapeutic agent for a Ruminant" on the basis of the Examiner report on 02-Feb-12. 17-Jul-2012 CSIR
156.## Publication no. 20100203178 entitled "Synergistic Herbal Composition" of Suresh Kumar Gupta, New Delhi, India was amended and then abandoned on the basis Examiner report on 20-Apr-12 and 14-Nov-11. 19-Jul-2012 CSIR
157. Based on the TKDL evidences filed for the application no  CA 2555728 entitled "Agents for sequestering serum aging factors and uses therefore" by Nu Skin International, Inc. (USA), CIPO has declared the application as ‘Dead’. 26-July-2012 CSIR
158. Kaneka Corporation, 2-4, Nakanoshima 3-chome Kita-ku, Osaka-shi, Osaka 530-8288 / Japan have withdrawn their application no EP2251024 for "Plant-Origin drug for preventing or improving Hyperuricemia" based on the TKDL evidences. 03-Aug-2012 CSIR
159.## Publication no. 20090269398 entitled "Compositions for the encapsulation of natural product extracts in oil medium in hard gelatin capsules and a method of encapsulation" of Vilambi NRK Reddy, United States was abandoned on the basis Examiner report on 18-Jan-2012. 14-Aug-2012 CSIR
160. Shiseido Company Ltd., 5-5 Ginza 7-chome Chuo-ku, Tokyo 104-8010 / Japan has amended the claims of the publication no. EP2269621 entitled "Agents for maturing, normalizing or stabilizing blood vessels and wrinkle-preventing and improving agents" based on the TKDL evidences. 20-Aug-2012 CSIR
161. Shiseido Company Ltd., 5-5 Ginza 7-chome Chuo-ku, Tokyo 104-8010 / Japan has amended the claims of the publication no. EP2319537 entitled "Stabilizer for Lymph Vessel" based on the TKDL evidences. 21-Aug-2012 CSIR
162. Kaneka Corporation, 2-4, Nakanoshima 3-chome Kita-ku, Osaka-shi, Osaka 530-8288 / Japan have withdrawn their application no EP2163252 for "Composition containing Licorice-derived Polyphenol" based on the TKDL evidences. 28-Aug-2012 CSIR
163. The Procter & Gamble Company, One Procter & Gamble Plaza, Cincinnati, OH 45202 / United States have withdrawn their application no EP2144591 for "Personal care compositions comprising an Antimicrobial Blend of essential oils or constituents thereof" based on the TKDL evidences. 31-Aug-2012 CSIR
164. CGPDTM refuses the application no. 212/DEL/2006 entitled "A herbal preparation for the prevention and management of various types of Carcinoma" filed by Prof. S. S. Trivedi, India, based on the TKDL evidences. 31-Aug-2012 CSIR
165. S.U.L.V.E. Ltd., P.O. Box 899, Business Center, 25147 Kfar-vradim / ISRAEL have withdrawn their application no EP1841320 for "Methods and pharmaceutical compositions useful for treating psoriasis" based on the TKDL evidences. 06-Sep-2012 CSIR
166. Maruzen Pharmaceuticals Co., Ltd., 14703-10, Mukaihigashi-cho Onomichi-shi, Hiroshima 7220062 / JAPAN has amended the claims of the publication no. EP1859834 entitled "Anti-Inflammatory agent" based on the TKDL evidences. 10-Sep-2012 CSIR
167. Morrison & Foerster LLP, 12531 High Bluff Drive, Suite 100, San Diego, CA, 92130-2040, United States, filed a patent application with publication no.  20100173022 entitled "Composition for the treatment of Diabetes Mellitus and Metabolic Syndrome", the Examiner rejected 12 claims based on the TKDL evidences. Application was abandoned on 27.03.2013. 19-Sep-2012 CSIR
168. Unhwa Corporation, 865-5 Hoseongdong 1-gaDeokjin-guJeonju-si, Jeollabuk-do 561-211 / South Korea have withdrawn their application no EP2227247 for "Anticancer composition comprising plant stem cell line derived from Taxus Cambium or Procambium" and application was closed on 20.09.2013 based on the TKDL evidences. 20-Sep-2012
(Official notification of EPO on this case is 07-Jun-2013)
CSIR
169. Based on the TKDL evidences filed for the application no  CA 2454171 entitled "Curcuminoid compositions exhibiting synergistic inhibition of the expression and/or activity of Cyclooxygenase-2" by Metaproteomics, LLC. (United States of America), CIPO has declared the application as ‘Dead’. 28-Sep-2012 CSIR
170. Amerilab Technologies, INC. Plymouth MN, filed a patent application with publication no.  20110117217 entitled "Method of using Guava Extract", the Examiner decided to cancel the claim 9 based on the TKDL evidences 01-Oct-2012 CSIR
171. In exercise of powers conferred by section 66 of the Patents Act, 1970, the Central Government declared Patent No. 252093 entitled "A Synergistic Ayurvedic/ Functional Food Bioactive Composition (Cincata) and a Process of Preparation Thereof" granted by CGPDTM (India) to M/s Avesthagen Limited, India, shall be deemed to be revoked. 18-Oct-2012 Govt. of India
172.## Examining division decided to refuse the application from the Applicant M/s Ayurvedic-Life International, LLC/ US on 27.06.2012 for Compositions for Diabetes treatment and Prophylaxis EP1660007 and application was closed on 10.10.2012 based on the TKDL evidences. 10-Oct-2012 CSIR
173. MDIP LLC, Post Office Box 2630 Montgomery Village, MD, 20886-2630, US, filed a patent application with publication no.  20100291249 entitled "Pomegranate-derived Products for the Treatment of Skin Sores and Lesions", the Examiner rejected 12 claims based on the TKDL evidences and application was abandoned on 17.05.2013. 23-Oct-2012 CSIR
174. Ganga Raju Gokaraju, Andhra Pradesh / India has amended the claims of the publication no. EP2303298 for "Compositions comprising extracts from Boswellia Serrata" based on the TKDL evidences. 24-Oct-2012 CSIR
175. Indena S.p.A., Via Ortles, 12, 20139 Milano / Italy has amended the claims of the publication no. EP2379095 for "Compositions Comprising Lipophilic extracts of Zingiber Officinale and Echinacea Angustifolia for the prevention and treatment of Gastro-Oesophageal Reflux" based on the TKDL evidences. 06-Nov-2012 CSIR
176. Ranbaxy Laboratories Limited., Plot No. 90, Sector-32 Gurgaon, Haryana 122001, Delhi / INDIA have withdrawn their application no EP2139504 for "Standardized Bioactive Herbal Extracts" based on the TKDL evidences and application was closed on 27.02.2013. 07-Nov-2012 CSIR
177. VDF Futureceuticals, Inc., 819 Dixie Highway, Momence, IL 60954 / United States of America has amended the claims of the publication no. EP2367526 for "Compositions and methods for alleviating hyposalivation and for providing oral comfort" based on the TKDL evidences. 08-Nov-2012 CSIR
178. Shiseido Company Ltd., 5-5 Ginza 7-chome Chuo-ku, Tokyo 104-8010 / JAPAN has amended the claims of the publication no. EP2275113 for "Skin circulation-improving agent and skin temperature-elevating agent" based on the TKDL evidences. 19-Nov-2012 CSIR
179. Based on the TKDL evidences filed for the application no  CA 2588119 entitled "Composition and method for facilitating the healing of non-healing and slow-healing wounds and ulcerations" by Berkson, Lindsey (United States of America), CIPO has declared the application as ‘Dead’. 19-Nov-2012 CSIR
180. Life Science Nutrition AS, Industrivegen 42 N-6160 Hovdebygda / Norway has amended the claims of the application no 2009222618 entitled "NGNA compositions and methods of use" based on the TKDL evidences. 20-Nov-2012 CSIR
181. Natural Disinfectant Technologies., Landhuis Joonchi, P.O. Box 837, Curacao / NETH. ANTILLES have withdrawn their application no EP2377543 for "Ophthalmic, pharmaceutical and other healthcare preparations with naturally ocurring plant compounds, extracts and derivatives" based on the TKDL evidences and application was closed on 17.04.2013 based on the TKDL evidences. 26-Nov-2012 CSIR
182. BASF Beauty Care Solutions France SAS, France have withdrawn their application no EP2157978 for "MC-1 R, MC-2 R, and MU Opioid Receptors Modulation" based on the TKDL evidences and application was closed on 11.03.2013 based on the TKDL evidences. 27-Nov-2012 CSIR
183. OMNICA GMBH, Plan 5, 20095 Hamburg / Germany have withdrawn their application no EP2144621 for "Guava Extract" based on the TKDL evidences and application was closed on 20.03.2013 based on the TKDL evidences. 07-Dec-2012 CSIR
184. Based on the TKDL evidences filed for the application no  CA 2334621 entitled "Composition and method for treatment of Inflammation and Pain in Mammals" by Metagenics, INC. (United States of America), CIPO has declared the application as ‘Dead’. 10-Dec-2012 CSIR
185. Based on the TKDL evidences filed for the application no  CA 2632684 entitled "Protein Kinase modulation by hops and acacia products" by Metaproteomics, LLC (United States of America), CIPO has declared the application as ‘Dead’. 11-Dec-2012 CSIR
186.## CGPDTM refuses the application no. 1576/DEL/2006 entitled "A Novel Herbal Composition Effective against Skin Disorders and to a Process for the Preparation Thereof" filed by Director, Central Council For Research in Unani Medicine (CCRUM), New Delhi, India, based on the TKDL evidences. 27-Dec-2012 CSIR
187. Legacy Healthcare Holding Ltd., 85, St. John Street, Valleta VLT 1165 / Malta has amended the claims of the publication no. EP2134316 for "Novel cosmetic and/or pharmaceutical compositions and applications thereof" based on the TKDL evidences. 22-Jan-2013 CSIR
188. Morinaga Milk Industry Co, LTD., 33-1, Shiba 5-chome, Minato-ku, Tokyo 108-8384 / Japan has amended the claims of the publication no. EP1941899 for "Agent for promoting Glucagon-like Peptide 1 Secretion, food or drink for promoting Glucagon-like Peptide 1 Secretion, agent for inhibiting postprandial increase in blood sugar level and food or drink for inhibiting postprandial increase in blood sugar level" based on the TKDL evidences. 24-Jan-2013 CSIR
189. Based on the TKDL evidences filed for the application no  CA 2570989 entitled "Product of vegetal origin comprising Proanthocyanidines and its preparation process" by Investigacion Y Nutricion, S.L. (Spain), CIPO has declared the application as ‘Dead’. 25-Jan-2013 CSIR
190. Based on the TKDL evidences filed for the application no  CA 2511431 entitled "Pharmaceutical compositions comprising Flavonoids and Menthol" by Immupharm A/S (Denmark), CIPO has declared the application as ‘Dead’. 28-Jan-2013 CSIR
191. Nuraging Biotech S.r.l., Località Piscinamanna, edif.5, 09010 Pula (CA) / Italy have withdrawn their application no. EP2046357 for "Antioxidant compositions comprising extracts of Myrtle and Rosemary" based on the TKDL evidences and application was closed on 13.05.2013. 01-Feb-2013 CSIR
192. Universiti Putra Malaysia, 43400 Upm Serdang, Selangor / Malaysia has amended the claims of the publication no. EP2367560 for "Anti-Cancer Nutraceutical Composition" based on the TKDL evidences. 28-Feb-2013 CSIR
193. OMNICA GMBH, Plan 5, 20095 Hamburg / GERMANY have withdrawn their application no. EP2323501 for "Reduced sesame seed derived pigments" based on the TKDL evidences and application was closed on 27.06.2013. 11-Mar-2013 CSIR
194. Based on the TKDL evidences filed for the application no  CA 2679847 entitled "Methods and compositions for promoting bone and joint health" by Metaproteomics, LLC. (United States of America), CIPO has declared the application as ‘Dead’. 14-Mar-2013 CSIR
195. Mars Incorporated / US, filed a patent application with publication no.  20100061944 entitled "Oral hygiene composition comprising myrtle", the Examiner rejected the claims based on the TKDL evidences. 14-Mar-2013 CSIR
196. CGPDTM refuses the application no. 1864/DEL/2006 entitled "A novel herbal composition and a process for preparation thereof effective against Diarrhaea and Dysentery" filed by Central Council for Research in Unani Medicines (CCRUM), India, based on the TKDL evidences. 14-Mar-2013 CSIR
197. CGPDTM refuses the application no. 1313/DEL/2006 entitled "A preparation for the treatment of running and stuffy nose, productive or non-productive cough with or without fever and to a process for the preparation thereof" filed by Central Council for Research of Ayurveda and Siddha, India, based on the TKDL evidences. 19-Mar-2013 CSIR
198. Jiangsu Kanion Pharmaceuticals Co Ltd/ China has amended the claims of the publication no. 182/MUMNP/2009 for "Cinnamomi and Poria composition and uses thereof" based on the TKDL evidences. 01-Apr-2013 CSIR
199. Metaproteomics LLC / United States have withdrawn their application no. EP2349305 for "Phytochemical Compositions and Methods for Activating Amp-Kinase" and application was closed on 25.07.2013 based on the TKDL evidences 09-Apr-2013 CSIR
200. Based on the TKDL evidences filed for the application no  CA 2649514 entitled "Licorice Polyphenol Preparation" by Kaneka Corporation (Japan), CIPO has declared the application as ‘Dead’. 12-Apr-2013 CSIR
201. Otkrytoe Aktsionernoe Obschestvo Zavod Ekologicheskoy Tekhniki, Moscow 115114 / Russia have withdrawn their application no. EP2060621 for "Wheat-germ oil concentrate, a method for the production thereof, a method for producing wheat-germ oil and a medicinal and prophylactic composition based thereon and used for treating sexual dysfunctions" and application was closed on 22.08.2013 based on the TKDL evidences. 03-May-2013 CSIR
202. INDENA S.p.A., Viale Ortles, 12, 20139 Milano / ITALY has amended the claims of the publication no. EP2262503 for "Formulations with Sanguinarine, Chelerythrine or Chelidonine for the treatment of Warts, Verrucas and Psoriatic Plaques" based on the TKDL evidences. 16-May-2013 CSIR
203. Wholesome Life Science Co., Ltd. 5F, 170, Sec 3 Ming-Chuan E. Rd Taipei 105 / Taiwan has amended the description of the publication no. EP1781235 for "Anti-hypersensitive Inflammation and Anti-allergy activities of Zingiber Zerumbet (l.) Smith" based on the TKDL evidences. 03-June-2013 CSIR
204. INDENA S.p.A., Viale Ortles, 12, 20139 Milano / ITALY has amended the claims and description of the publication no. EP2379092 for "Compositions comprising a Lipophilic extract of Zingiber Officinale and an extract of Cynara Scolymus" based on the TKDL evidences. 14-June-2013 CSIR
205. Maria Wilhemina Meijs / US, filed a patent application with publication no.  20120231032 entitled "Agent for expelling parasites in humans, animals or birds", the Examiner rejected 1-19 claims based on the TKDL evidences. 24-Jun-2013 CSIR
206. Otkrytoe Aktsionernoe Obschestvo Zavod Ekologicheskoy Tekhniki I Ekopitaniya 'Diod' / Russia have withdrawn their application no. EP1825861 for "Anti-inflammatory extract and agent and method for the production thereof" and application was closed on 09.10.2013 based on the TKDL evidences. 09-Jul-2013 CSIR
207. CGPDTM refuses the application no. 1865/DEL/2006 entitled "A novel herbal composition effective against general weakness and a process thereof" filed by Central Council for Research in Unani Medicines (CCRUM), India, based on the TKDL evidences. 19-Jul-2013 CSIR
208.## N. B. Baktha Reddy, Chennai, India, filed a patent application with publication no.  20130017279 entitled "Formulations for treatment of skin disorders", the Examiner decided to reject the claims 1-15 on 26-Jul-13 26-Jul-2013 CSIR
209. Gogaraju Ganga Raju/ India has amended the claims of the publication no. 881/CHENP/2008 for "Process for producing enriched fractions of Tetrahydroxycurcumin and Tetrahydrotetrahydroxycurcumin" based on the TKDL evidences. 05-Aug-2013 CSIR
210. F. Coy, Johannes F. , Mestemacher GmbH / Germany have withdrawn their application no. EP2094094 for "Composition comprising a milled cereal product" and application was closed on 13.11.2013 based on the TKDL evidences. 07-Aug-2013 CSIR
211. Based on the TKDL evidences filed for the application no  CA 2618613 entitled "Protein Kinase modulation by Hops and Acacia products" by Metaproteomics, LLC (United States of America), CIPO has declared the application as ‘Dead’. 09-Aug-2013 CSIR
212. Mehlhorn, Heinz / Germany, King Saud University / Saudi Arabia has amended the description of the publication no. EP2493490 for "Pharmaceutical or Veterinary Medical preparation obtained from Coconut (Cocos Nucifera) and Onion (Allium Cepa) for controlling Flatworms (Plathelminthes) and/or Threadworms (Nematodes) in animals or humans" based on the TKDL evidences. 20-Aug-2013 CSIR
213. Piramal Enterprises Limited / India have withdrawn their application no. EP1998727 for "Herbal composition for treatment of infections caused by Dermatophytes" based on the TKDL evidences. 22-Aug-2013 CSIR
214. Phenolics, LLC, P.O. Box 2439, 846 San Carlos Avenue, El Granada, CA 94108-2439 / US has amended the claims of the publication no. EP1572219 for "Efficient method for producing compositions enriched in total phenols" based on the TKDL evidences. 23-Sep-2013 CSIR
215. CGPDTM refuses the application no. 1642/DEL/2006 entitled "A novel herbal composition effective against headache and a process for the preparation thereof" filed by Central Council for Research in Unani Medicines (CCRUM), India, based on the TKDL evidences. 23-Sep-2013 CSIR
216. CGPDTM refuses the application no. 369/DEL/2005 entitled "A composition for the treatment of sex drive and weakness" filed by Shrivastav, Yashvardhan and Shrivastav, Anand, India, based on the TKDL evidences. Sep-2013 CSIR
217. Amorepacific Corporation, 181, 2-ga Hangang-ro Yongsan-gu, Seoul 140-777 / Republic of Korea has amended the claims of the publication no. EP2152281 for "Composition for treatment of ischemic heart disease, facilitation of blood circulation and angiogenesis, improving skin beauty, improving male sexual function containing ginseng berry extract" based on the TKDL evidences. 04-Oct-2013 CSIR
218. CGPDTM refuses the application no. 3387/DELNP/2004 entitled "Formulations useful in the treatment of male and female impotence" filed by INDENA S.P.A, Italy, based on the TKDL evidences. 17-Oct-2013 CSIR
219. Based on the TKDL evidences filed for the application no  CA 2584124 entitled "Flavonoid composition for treating oral diseases" by Unigen Pharmaceuticals, INC. (United States of America), CIPO has declared the application as ‘Dead’. 21-Oct-2013 CSIR
220. Based on the TKDL evidences filed for the application no  CA 2641950 entitled "All natural multivitamin and multimineral dietary supplement formulations for enhanced absorption and biological utilization" by Mannatech, INC. (United States of America), CIPO has declared the application as ‘Dead’. 28-Oct-2013 CSIR
221. Based on the TKDL evidences filed for the application no  CA 2684853 entitled "Dietary supplement for promoting wellness and weight loss and methods of administering the same" by Reliv International, Inc. (United States of America), CIPO has declared the application as ‘Dead’. 12-Nov-2013 CSIR
222. DSM IP Assets B.V., Het Overloon 1, 6411 TE Heerlen / Netherlands have withdrawn their application no. EP2124636 for "Novel use of (-)-Epigallocatechin Gallate" and application was closed on 18.02.2014 based on the TKDL evidences. 15-Nov-2013 CSIR
223. Société des Produits Nestlé S.A., P.O.Box 353, 1800 Vevey / Switzerland have withdrawn their application no. EP2204176 for "Nutritional Composition" and application was closed on 18.02.2014 based on the TKDL evidences. 18-Nov-2013 CSIR
224. Mary Kay, Inc., 16251 N. Dallas Parkway, P.O. Box 799045, Dallas, TX 75379-9045 / US has amended the claims of the publication no. EP2455134 for "Magnolia extract containing compositions" based on the TKDL evidences. 29-Nov-2013

(Applicant amended a set of claims in which 2 claims were deleted)
CSIR
225. Chongquing institute of Ecological Materia Medica Co Limited / China and Phynova Limited/ Great Britain have withdrawn their application no. EP2089044 for "Anti-obesity product and it's method of preparation" based on the TKDL evidences and application was closed on 06.03.2014. 04-Dec-2013 CSIR
226. Based on the TKDL evidences filed for the application no  CA 2606392 entitled "Hair Tonic" by INDENA S.P.A. (Italy), CIPO has declared the application as ‘Dead’. 05-Dec-2013 CSIR
227. Metaproteomics, LLC, 100 Avenida La Pata, San Clemente, CA 92673 / US has amended the claims of the publication no. EP2253314 for "Curcuminoid compositions exhibiting synergistic inhibition of the expression and/or activity of cyclooxygenase-2" based on the TKDL evidences. 11-Dec-2013 CSIR
228. CGPDTM refuses the application no. 1962/MUM/2008 entitled "A herbal formulation for treating sickle cell disease" filed by Atul Desai, India, based on the TKDL evidences. 12-Dec-2013 CSIR
229. Taichung Veterans General Hospital / Taiwan, filed a patent application with publication no.  20130095171 entitled "Herbal composition and method for treatment of airway inflammation using the same", the Examiner rejected 7-18 claims based on the TKDL evidences. 17-Dec-2013 CSIR
230. Peplin Research Pty Ltd, Ground Floor, South Tower, 527 Gregory Terrace, Bowen Hills, QLD 4006 / Australia have amended their application no. EP1296698 for "Therapeutic Agents - II" based on the TKDL evidences. 18-Dec-2013 CSIR
231. Based on the TKDL evidences filed for the application no  CA 2412435 entitled "Phytonutrient formula for the relief of chronic pain resulting from inflammation" by WYETH (United States of America), CIPO has declared the application as ‘Dead’. 03-Jan-2014 CSIR
232. Universiti Putra Malaysia, UPM Serdang, 43400 Selangor Darul Ehsan / Malaysia has amended the claims of the publication no. EP2349302 for "Cardioprotective effects of Nutraceuticals isolated from Nigella Sativa seeds" based on the TKDL evidences. 20-Jan-2014 CSIR
233.## Santalis Pharmaceuticals Inc., US, filed a patent application with publication no.  20130005830 entitled "Sandalwood oil and its uses", the Examiner decided to reject the claims 1-4 and 6-8 on 18-Oct-13. Applicant amended the claims on 21-Jan-2014. Examiner again rejected the claims 1-4 and 6-8 on 22-Apr-14 21-Jan-2014 CSIR
234. Based on the TKDL evidences filed for the application no  CA 2731454 entitled "A herbal and vitamin C composition used for treating inflammation and the mainenance of good health" LEBLANC, RUSSELL (Canada), CIPO has declared the application as ‘Dead’. 11-Feb-2014 CSIR
235. Kao Corporation 14-10, Nihonbashi-Kayabacho, 1-chome Chuo-ku Tokyo 103-8210 / Japan have withdrawn their application no. EP1993522 for "Resveratrol and/or Grape leaf extract as i.a. Endurance Improver, Anti-aging agent, Muscle strength improver" based on the TKDL evidences. 21-Feb-2014 CSIR
236.## Somalabs Inc., US, filed a patent application with publication no.  20120115891 entitled "Method for the induction of a reward response by modulation of dopaminergic systems in the central nervous system", the Examiner decided to reject the claims 1-3 and 11-13 on 25-Oct-13. Applicant amended the claims on 25-Feb-2014. Examiner again rejected the claims 1 and 11-13 on 23-Apr-14 25-Feb-2014 CSIR
237. CGPDTM refuses the application no. 1734/DEL/2007 entitled "A novel herbal composition for the treatment of Eczema" filed by Central Council for Research in Unani Medicines (CCRUM), India, based on the TKDL evidences. 10-Mar-2014 CSIR
238. CGPDTM refuses the application no. 1735/DEL/2007 entitled "A novel herbal preparation for the treatment of Sinusitis" filed by Central Council for Research in Unani Medicines (CCRUM), India, based on the TKDL evidences. 10-Mar-2014 CSIR
239. CGPDTM refuses the application no. 907/DEL/2005 entitled "A synergistic herbal formulation useful in reducing undesirable after-effects of alcoholic beverages" filed by Anil Sharma, India, based on the TKDL evidences. 12-Mar-2014 CSIR
240. Metaproteomics, LLC / US have withdrawn their application no. EP2269598 for "Curcuminoid compositions exhibiting synergistic inhibition of the expression and/or activity of cyclooxygenase-2" based on the TKDL evidences. 17-Mar-2014 CSIR
241. Hwang; Jae Kwan; Cho; Yu-Mi; Kim; Gyu Hoi; South Korea, has amended the claims of the application no.  20110118346 entitled "Novel use of Lignan-type compounds or extract of Nutmeg or Aril of Nutmeg comprising the same" and Examiner again rejects the claim 9 based on the TKDL evidences 27-Mar-2014 CSIR
242.## CGPDTM refuses the application no. 193/CHE/2007 entitled "A herbal preparation effective in the prevention and management of Rheumatoid Arthritis and associated compliants" filed by Dr. Swaminathan, India, based on the TKDL evidences. 28-Mar-2014 CSIR
243. Nanyang Polytechnic / Singapore have withdrawn their application no. EP2416793 for "A plant extract comprising statins and preparation techniques and uses thereof" based on the TKDL evidences. 1-Apr-2014 CSIR
244. Mars, Incorporated / US have withdrawn their application no. EP2293689 for "Food product" based on the TKDL evidences. 30-Apr-2014 CSIR
245. Ott, David M., 777 Panoramic Way, Berkeley, CA 94704 / US have withdrawn their application no. EP1901701 for "Personal care and medicinal products incorporating bound Organosulfur groups" based on the TKDL evidences. 15-May-2014 CSIR
246. Based on the TKDL evidences filed for the application no  CA 2574518 entitled "Pharmaceutical composition and non dependence coffee comprising edible Carboxylic Acid and/or its Acid Salt and Coffeine" SHIAO, SHIN-JEN (Taiwan), CIPO has declared the application as ‘Dead’. 22-May-2014 CSIR
247. Kim; Hyoung-Jun / Korea, filed a patent application with publication no.  20120329739 entitled "Composition for preventing or treating Poliosis or Vitiligo comprising a Pueraria genus plant extract or Puerarin", the Examiner decided to reject the claims on 20-Mar-14. Applicant amended the claims on 19-Jun-14. Examiner again rejected the claims on 06-Aug-14 based on the TKDL evidences. 06-Aug-2014 CSIR
248. Somalabs, Inc., 40 Allen Road, South Burlington, VT 05403 / US have withdrawn their application no. EP2419508 for "Method for the induction of a reward response by modulation of dopaminergic systems in the central nervous system" based on the TKDL evidences. 13-Aug-2014 CSIR
*Now Department of AYUSH
**Now NISCAIR
***M/s Livzon has now accepted the TKDL evidences that Kalamegha (Andrographis) and Pudina (Mint) use for the treatment of Avian Influenza was known to Indian Systems of Medicine and has withdrawn its claim on independent use of Kalamegha & Mint for the treatment of Avian Influenza and accordingly has modified its earlier claims on 05/07/2010.
**** M/s Data Medica Padova S.p.A submitted that his claims are on Pistacia terebinthus and not on Pistacia vera for which TKDL evidences were submitted, EPO accepted the position and re - granted the Patent.
## The Examiner rejected/cancelled the claims by utilizing the TKDL independently without the submission of the Evidences by TKDL.

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